Dosing and Titration

Titration with GRALISE

95% of patients tolerated a 2-week titration to 1800 mg/day when GRALISE was taken once daily with an evening meal1

GRALISE 2-week titration2

GRALISE 2-week titration graph

  • Discontinuation due to adverse events (AEs) during the 2-week titration period was 3.6% for GRALISE and 3.0% for placebo1
  • Overall rates of discontinuation due to AEs were 9.7% for GRALISE vs 6.9% with placebo2

Dosage based on renal function2

Creatinine Clearance
(Once daily with evening meal)
≥60 1800 mg
30 to 60 600 mg to 1800 mg
<30 GRALISE should not be administered
Patients receiving hemodialysis GRALISE should not be administered